RESEARCH GROUP LEADERS

Shaker Chuck Farah
Director of CEPID B3

Structure and Function of Proteins

Graduated in Biochemistry and Chemistry from the University of Toronto (1985), with a Master’s in Biochemistry from the same institution (1988) and a PhD in Biological Sciences (Biochemistry) from the University of São Paulo (1994). He is currently a Full Professor in the Department of Biochemistry at the Institute of Chemistry and Vice-Director of the Institute of Chemistry at the University of São Paulo. His research focuses on understanding the structural basis of processes important for complex bacterial behaviors, using the phytopathogen Xanthomonas citri, the causative agent of citrus canker, as a model.

E-mail: chsfarah@iq.usp.br

 (11) 97400-3454

Aline Maria da Silva
Research group leader and Deputy Director (2023-2024)

Molecular characterization of bacteriophages and determinants of phage-bacteria interaction.

Graduated in Pharmaceutical Sciences and with a PhD in Biochemistry from the University of São Paulo, with postdoctoral training at the Saint Louis University School of Medicine, Saint Louis, USA. Since 1991, she has been a Professor in the Department of Biochemistry at the Institute of Chemistry at USP, working on the isolation and characterization of bacteriophages and factors affecting phage-bacteria interactions, with a focus on applications in phage therapy.

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Beny Spira
Research group leader, teaching and dissemination coordinator

Adaptation, mutagenesis and evolution of bacteria

PhD from Tel Aviv University, with postdoctoral training from the University of Sydney. He is currently an Associate Professor III at the Institute of Biomedical Sciences at the University of São Paulo and Coordinator of the Bacterial Genetics Laboratory. His research focuses on studying mutagenesis systems, bacterial adaptation and evolution, and mechanisms of antibiotic resistance and tolerance.

E-mail: benys@usp.br

 11 30918346

Cristiane Rodrigues Guzzo Carvalho
Research group leader

Structural and functional study of secretory systems and bacterial c-di-GMP signaling. Structural study of respiratory virus proteins

Graduated in Chemistry with technological attributes and in Biotechnology (2005), with a PhD and postdoctoral training (2011) in Biological Sciences (Biochemistry) from the University of São Paulo. In 2015-2016, she participated in a sabbatical project in Professor Gabriel Waksman’s laboratory (London), exploring additional techniques in structural biology. She is currently studying bacterial secretory systems, signaling, and the biochemistry of the SARS-CoV-2 virus at the Institute of Biomedical Sciences at the University of São Paulo, integrating molecular biology, protein expression, structural biology techniques, and conventional biochemical methods.

Cristina Unicamp perfil
Cristina Elisa Alvarez Martinez
Research group leader

Gene Regulation in Bacteria; Bacterial Secretion Systems

Graduated in Biological Sciences from UFRJ, with a Master’s in Molecular Biology from the Carlos Chagas Filho Institute of Biophysics (UFRJ) and a PhD in Biochemistry from the Institute of Chemistry from the University of São Paulo. She completed her postdoctoral training at the University of Texas Health Science Center at Houston. She leads studies on protein secretion systems in plant pathogenic bacteria (such as Xanthomonas sp.) and animal pathogenic bacteria (such as Stenotrophomonas sp. and Acinetobacter sp.) at the Institute of Biology at the State University of Campinas. Her research also includes transcriptional regulators, aiming to uncover the role of important families of regulators in bacterial responses to environmental changes.

Frederico Gueiros Filho é Professor Associado do Depto de Bioquímica - IQ USP - Foto: Cecília Bastos/USP Imagem
Frederico J. Gueiros Filho
Research group leader, Innovation Coordinator

Molecular mechanisms that control bacterial growth and division

Frederico Gueiros-Filho He obtained his PhD from Harvard University in 1998, followed by a postdoctoral training with Rich Losick (Harvard MCB) from 1998 to 2002. Since 2003, his laboratory at the Institute of Chemistry at the University of São Paulo has been studying the molecular mechanisms that enable bacterial cells to grow and divide, as well as contributing to the validation of new targets for antibiotics.

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Germán Gustavo Sgro
Research group leader

Structural, molecular and functional characterization of protein macro-complexes of interest in microbiology

Bachelor’s degree in Chemistry (2005), Licentiate in Biotechnology (2009), and PhD in Biological Sciences (2014) from the Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, Argentina. Worked as a postdoctoral researcher at the Institute of Chemistry of the University of São Paulo (USP, 2014-2019) under the supervision of Professor Shaker Chuck Farah. Held a position as a professor for the course ‘A proposal to read, write, and learn better upon entering university’ (2008-2010) and as an assistant in the Department of Organic Chemistry (2010-2012) at the Faculty of Biochemical and Pharmaceutical Sciences of the National University of Rosario, Argentina. Also worked as an assistant in the Chair of Cellular Biology and the Laboratory of Bromatology (2012-2013) for the University Technician course in Chemistry at the ‘General San Martin’ Polytechnic Institute, National University of Rosario, Argentina. Completed a fellowship (2016-2017) at the Department of Biological Sciences at Birkbeck College in London, UK, where he held the position of Associate Research Fellow. Currently, he is an Associate Professor in the Department of BioMolecular Sciences at the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo.

Henrique Ferreira
Research group leader.

Biology of bacteria and their viruses.

Graduated in Biological Sciences (1995) and Master in Molecular Genetics and Microorganisms from the State University of Campinas (UNICAMP, 1998). Ph.D. in Biochemistry from the University of Oxford, UK (2002), where he worked on chromosomal integrity and site-specific recombination in Professor David Sherratt’s group. Postdoctoral research on bacterial chromosomal segregation in Professor Jeff Errington’s group (2002-2004), Sir William Dunn School of Pathology, University of Oxford, UK. Postdoctoral research investigating protein function based on structure at LNLS-Campinas (2004-2006). FAPESP Young Researcher (2006-2009). Currently, work as an Assistant Professor 3 in the Department of Biochemistry and Microbiology at the Institute of Biosciences, Rio Claro, SP (UNESP). He leads a research group investigating various aspects of bacterial biology, with a particular focus on chromosomal dynamics and cell division in the phytopathogen Xanthomonas citri, the causal agent of citrus canker. He is also involved in the development of agricultural pesticides using natural, synthetic, and bacteriophage active compounds.

João Carlos Setubal
Research group leader and Deputy Director

Genomics, metagenomics and bioinformatics

PhD in computing from the University of Washington. He works on the development and use of computational tools for analyzing omics data, with an emphasis on genomics and metagenomics

José Freire da Silva Neto
Research group leader

Molecular Genetics of Bacteria

Graduated in Biological Sciences from the Institute of Biosciences at the University of São Paulo (IB-USP) and holds a PhD in Microbiology from the Institute of Biomedical Sciences (ICB-USP). Completed postdoctoral research at both ICB-USP and IB-USP, and earned a habilitation from the Ribeirão Preto Medical School (FMRP-USP). Currently, he is an Associate Professor at FMRP-USP, Coordinator of the Graduate Program in Cellular and Molecular Biology at FMRP-USP, and a PQ2 fellow of CNPq. His research projects focus on Gene Expression Regulation, Bacterial Pathogenicity, Metal Homeostasis Mechanisms and Nutritional Immunity, and Bacterial Secretion Systems. The primary organism studied in his research is the environmental pathogen Chromobacterium violaceum.

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Leonardo Talachia Rosa
Research group leader

Bacterial metabolism/ Structural Biology

Professor at the Institute of Biology at the State University of Campinas (UNICAMP) and Young Researcher funded by FAPESP. He is currently working with membrane transporters in the bacterium Bordetella pertussis. He has a PhD from The University of Sheffield, a postdoctoral degree from the European Institute of Chemistry and Biology and a postdoctoral degree from the USP Chemistry Institute. Fascinated by bacterial metabolism, he is especially interested in the characterization of biological processes through structural biology and CryoEM.

Marcelo Brocchi
Research group leader – PI

Bacterial pathogenicity

Completed his Master’s degree (1990-1993) and PhD (1993-1997) in Microorganism Genetics at the University of Campinas – UNICAMP, Campinas, SP. Part of the PhD project was carried out at IRIS Siena, Italy (1993-1995). She completed her Post-Doctorate (1997-1998) at UNICAMP developing research into bacterial pathogenicity. He began his career in 1998 as a professor of Microbiology at the University of São Paulo, Faculty of Medicine of Ribeirão Preto. In 2004, he transferred to Unicamp, as a PhD professor (2004-2007) and as an associate since 2007. Research in the laboratory is related to the study of the pathogenicity of Gram-negative bacteria. The group also works on the development of bacterial mutants to study gene function and virulence attenuation. One strategy involves attenuating S. enterica strains by deleting genes encoding nucleoid-associated proteins (NAPs). Recently, the group began to investigate the mechanisms of resistance and mode of action of antimicrobials.

Marcio Vinicius Bertacine Dias
Research group leader

Structural Biology, Mycobacteria, Actinomycetes, Antimicrobials

Graduated in Biological Sciences from UNESP-IBILCE, PhD in Molecular Biophysics from the same institution. He held a postdoctoral degree at the University of Cambridge developing projects in the area of ​​biosynthesis of natural products and application of the fragment-based drug development approach. He is currently a Prof. Associate of the Department of Microbiology, ICB-USP. He works with structural biology and other biophysical techniques to study enzymes from microorganisms.

Marco Aurélio Takita
Research group leader

Functional genomics of citrus and its pathogens

Biologist graduated from USP with a PhD in Sciences (Biochemistry) from IQ also from USP and post-doctorate at the Salk Institute for Biological Studies (CA, United States). He is currently Researcher VI at the Sylvio Moreira Citriculture Center – IAC and a 1D Productivity fellow from CNPq. In addition to CEPID, he is a PP in a FAPESP theme on microbiome, and in an INCT (FAPESP/CNPq) and he also participates in an NPOP FAPESP on citrus gene editing.

Marilis do Valle Marques
Research group leader

Gene regulation in the stress response in bacteria

Graduated in Biological Sciences from the University of Campinas (UNICAMP), with a PhD in Biochemistry from the University of São Paulo (USP), and postdoctoral training in Molecular Biology at the University of California (UCLA). She is currently an Associate Professor 3 in the Department of Microbiology at USP. Her projects focus on gene regulation in the bacterium Caulobacter, in collaboration with researchers from Brazil and abroad.

Regina Lúcia Baldini
Research group leader

Signal Transduction in Bacteria

Graduated in Biological Sciences from the State University of Campinas (UNICAMP), with a Master’s in Genetics from the same institution and a PhD in Biochemistry (IQ-USP). She completed her postdoctoral training at Massachusetts General Hospital/Harvard Medical School and was a Young Researcher in the Department of Microbiology (ICB-USP). She joined the Institute of Chemistry, USP, in 2005, where she is currently an Associate Professor. Her research focuses on gene expression and signaling in bacteria.

Rita de Cassia Café Ferreira
Research group leader

Research and Teaching in Microbiology

She holds a degree in Biological Sciences from the Federal University of Rio de Janeiro (UFRJ) and a PhD from the Carlos Chagas Filho Institute of Biophysics (1996). She has been a professor at the Department of Microbiology at the University of São Paulo since 2000. She works in Microbiology Teaching as coordinator of the #Adote Project (2013). Responsible for the Teaching area of ​​the Brazilian Society of Microbiology, since 2018.

Roberto Kopke Salinas
Research group leader

Protein RMN

Graduated in Chemistry (1996) and with a Master’s in Biochemistry (2000) from the University of São Paulo (USP). He completed his PhD in Chemistry at Utrecht University, Netherlands (2005), and postdoctoral training at USP (2005-2008) and Florida State University (2009-2011). He is currently an Associate Professor in the Department of Biochemistry at the Institute of Chemistry at USP. He has experience in Biophysics, with a focus on Molecular Biophysics, primarily applying Nuclear Magnetic Resonance methods to study the structure and dynamics of proteins in solution.

Robson Francisco de Souza
Bioinfomatics Module Coordinator

Comparative Genomics / Evolution and Classification of Proteins

Bachelor of Molecular Sciences, Master of Science (Biotechnology) and Doctor of Science (Biochemistry) from the University of São Paulo. Postdoctoral in Bioinformatics at the National Center for Biotechnology Information (NCBI) of the National Library of Medicine, NIH/USA. Develops research in the area of ​​protein evolution and classification, as well as comparative analysis of genomes with a focus on identifying putative functions of gene families, and analyzing the evolutionary history of viruses, microorganisms and biomolecular systems.

Rodrigo Galhardo
Rodrigo da Silva Galhardo
Research group leader

Genetics and Molecular Biology of bacteria, with emphasis on: mobile elements, DNA repair and mutagenesis, control of gene expression.

Biologist from UFRJ, with a Master’s degree in Biophysics from UFRJ. PhD in Microbiology from USP, Post-Doctorate at USP and Baylor College of Medicine with a scholarship from the PEW Latin American Fellows program. Professor of the Dept. of Microbiology at ICB USP since 2011, being Prof. Associate since 2022. Has research projects on the biology of integrative and conjugative elements of Proteus mirabilis and on the SOS response of Pseudomonas aeruginosa and Caulobacter crescentus. CNPq Level 2 Researcher.

Sandro Roberto Marana
Research group leader

Catalysis and Thermostability in Enzymes

Graduated in Biological Sciences from the USP Biosciences Institute (1991). Master’s (1994), Doctorate (1999) and Post-Doctorate (2001) in Biological Sciences – Biochemistry from the Institute of Chemistry at USP. Associate Professor at the USP Chemistry Institute since 2001. Works in the area of ​​Biochemistry with a focus on Enzymology.